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Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1
Activated PI3K Delta Syndrome (APDS) is a primary immunodeficiency disease caused by activating mutations in either the leukocyte-restricted p110δ catalytic (PIK3CD) subunit or the ubiquitously expressed p85α regulatory (PIK3R1) subunit of class IA phosphoinositide 3-kinases (PI3Ks). There are two c...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5338455/ https://ncbi.nlm.nih.gov/pubmed/28167755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617244114 |
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