Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1

Activated PI3K Delta Syndrome (APDS) is a primary immunodeficiency disease caused by activating mutations in either the leukocyte-restricted p110δ catalytic (PIK3CD) subunit or the ubiquitously expressed p85α regulatory (PIK3R1) subunit of class IA phosphoinositide 3-kinases (PI3Ks). There are two c...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Dornan, Gillian L., Siempelkamp, Braden D., Jenkins, Meredith L., Vadas, Oscar, Lucas, Carrie L., Burke, John E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338455/
https://ncbi.nlm.nih.gov/pubmed/28167755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617244114
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