SGK3 sustains ERα signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis

Many estrogen receptor alpha (ERα)-positive breast cancers initially respond to aromatase inhibitors (AIs), but eventually acquire resistance. Here, we report that serum- and glucocorticoid-inducible kinase 3 (SGK3), a kinase transcriptionally regulated by ERα in breast cancer, sustains ERα signalin...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Wang, Yuanzhong, Zhou, Dujin, Phung, Sheryl, Warden, Charles, Rashid, Rumana, Chan, Nymph, Chen, Shiuan
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338386/
https://ncbi.nlm.nih.gov/pubmed/28174265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612991114
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