Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties

Osteoporosis is characterised by trabecular bone loss resulting from increased osteoclast activation and unbalanced coupling between resorption and formation, which induces a thinning of trabeculae and trabecular perforations. Bisphosphonates are the frontline therapy for osteoporosis, which act by...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Ma, Shaocheng, Goh, En Lin, Jin, Andi, Bhattacharya, Rajarshi, Boughton, Oliver R., Patel, Bhavi, Karunaratne, Angelo, Vo, Nghia T., Atwood, Robert, Cobb, Justin P., Hansen, Ulrich, Abel, Richard L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338252/
https://ncbi.nlm.nih.gov/pubmed/28262693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43399
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