CD49a Expression Defines Tissue-Resident CD8(+) T Cells Poised for Cytotoxic Function in Human Skin

Tissue-resident memory T (Trm) cells form a heterogeneous population that provides localized protection against pathogens. Here, we identify CD49a as a marker that differentiates CD8(+) Trm cells on a compartmental and functional basis. In human skin epithelia, CD8(+)CD49a(+) Trm cells produced inte...

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Gepubliceerd in:Immunity
Hoofdauteurs: Cheuk, Stanley, Schlums, Heinrich, Gallais Sérézal, Irène, Martini, Elisa, Chiang, Samuel C., Marquardt, Nicole, Gibbs, Anna, Detlofsson, Ebba, Introini, Andrea, Forkel, Marianne, Höög, Charlotte, Tjernlund, Annelie, Michaëlsson, Jakob, Folkersen, Lasse, Mjösberg, Jenny, Blomqvist, Lennart, Ehrström, Marcus, Ståhle, Mona, Bryceson, Yenan T., Eidsmo, Liv
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5337619/
https://ncbi.nlm.nih.gov/pubmed/28214226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.01.009
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