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In Vitro and In Vivo Modeling of Hydroxypropyl Methylcellulose (HPMC) Matrix Tablet Erosion Under Fasting and Postprandial Status

PURPOSE: To develop a model linking in vitro and in vivo erosion of extended release tablets under fasting and postprandial status. METHODS: A nonlinear mixed-effects model was developed from the in vitro erosion profiles of four hydroxypropyl methylcellulose (HPMC) matrix tablets studied under a ra...

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Publicat a:Pharm Res
Autors principals: Guiastrennec, Benjamin, Söderlind, Erik, Richardson, Sara, Peric, Alexandra, Bergstrand, Martin
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336534/
https://ncbi.nlm.nih.gov/pubmed/28155077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-017-2113-7
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