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Method to recover a lipophilic drug from hydroxypropyl methylcellulose matrix tablets

A reverse-phase high-performance liquid chromatographic (HPLC) method for recovery of the lipophilic drug, alprazolam, from matrix tablets containing the hydrophilic polymer hydroxypropyl methylcellulose (HPMC) was developed. Lipophilic drugs, such as alprazolam, are difficult to completely extract...

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Detalhes bibliográficos
Main Authors: Williams, Robert O., Sykora, Matthew A., Mahaguna, Vorapann
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750474/
https://ncbi.nlm.nih.gov/pubmed/14727883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/pt020208
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