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Loss of Glyoxalase 1 Induces Compensatory Mechanism to Achieve Dicarbonyl Detoxification in Mammalian Schwann Cells

The glyoxalase system is a highly specific enzyme system existing in all mammalian cells that is responsible for the detoxification of dicarbonyl species, primarily methylglyoxal (MG). It has been implicated to play an essential role in preventing the increased formation of advanced glycation end pr...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Morgenstern, Jakob, Fleming, Thomas, Schumacher, Dagmar, Eckstein, Volker, Freichel, Marc, Herzig, Stephan, Nawroth, Peter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336158/
https://ncbi.nlm.nih.gov/pubmed/27956549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.760132
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