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Analysis of mtDNA/nDNA ratio in mice

The mitochondrial DNA (mtDNA) lacks a protection provided by the nucleosomes in the nuclear DNA and does not have a DNA repair mechanism, making it highly susceptible to damage, which can lead to mtDNA depletion. MtDNA depletion compromises the efficient function of cells and tissues and thus impact...

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Bibliografiske detaljer
Udgivet i:Curr Protoc Mouse Biol
Main Authors: Quiros, Pedro M., Goyal, Aashima, Jha, Pooja, Auwerx, Johan
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5335900/
https://ncbi.nlm.nih.gov/pubmed/28252199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpmo.21
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