Normalization and microbial differential abundance strategies depend upon data characteristics

BACKGROUND: Data from 16S ribosomal RNA (rRNA) amplicon sequencing present challenges to ecological and statistical interpretation. In particular, library sizes often vary over several ranges of magnitude, and the data contains many zeros. Although we are typically interested in comparing relative a...

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Detaylı Bibliyografya
Yayımlandı:Microbiome
Asıl Yazarlar: Weiss, Sophie, Xu, Zhenjiang Zech, Peddada, Shyamal, Amir, Amnon, Bittinger, Kyle, Gonzalez, Antonio, Lozupone, Catherine, Zaneveld, Jesse R., Vázquez-Baeza, Yoshiki, Birmingham, Amanda, Hyde, Embriette R., Knight, Rob
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2017
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5335496/
https://ncbi.nlm.nih.gov/pubmed/28253908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40168-017-0237-y
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