Normalization and microbial differential abundance strategies depend upon data characteristics

BACKGROUND: Data from 16S ribosomal RNA (rRNA) amplicon sequencing present challenges to ecological and statistical interpretation. In particular, library sizes often vary over several ranges of magnitude, and the data contains many zeros. Although we are typically interested in comparing relative a...

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Bibliografiske detaljer
Udgivet i:Microbiome
Main Authors: Weiss, Sophie, Xu, Zhenjiang Zech, Peddada, Shyamal, Amir, Amnon, Bittinger, Kyle, Gonzalez, Antonio, Lozupone, Catherine, Zaneveld, Jesse R., Vázquez-Baeza, Yoshiki, Birmingham, Amanda, Hyde, Embriette R., Knight, Rob
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5335496/
https://ncbi.nlm.nih.gov/pubmed/28253908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40168-017-0237-y
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