Normalization and microbial differential abundance strategies depend upon data characteristics

BACKGROUND: Data from 16S ribosomal RNA (rRNA) amplicon sequencing present challenges to ecological and statistical interpretation. In particular, library sizes often vary over several ranges of magnitude, and the data contains many zeros. Although we are typically interested in comparing relative a...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Microbiome
Main Authors: Weiss, Sophie, Xu, Zhenjiang Zech, Peddada, Shyamal, Amir, Amnon, Bittinger, Kyle, Gonzalez, Antonio, Lozupone, Catherine, Zaneveld, Jesse R., Vázquez-Baeza, Yoshiki, Birmingham, Amanda, Hyde, Embriette R., Knight, Rob
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5335496/
https://ncbi.nlm.nih.gov/pubmed/28253908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40168-017-0237-y
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