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Multiscale image analysis reveals structural heterogeneity of the cell microenvironment in homotypic spheroids

Three-dimensional multicellular aggregates such as spheroids provide reliable in vitro substitutes for tissues. Quantitative characterization of spheroids at the cellular level is fundamental. We present the first pipeline that provides three-dimensional, high-quality images of intact spheroids at c...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Schmitz, Alexander, Fischer, Sabine C., Mattheyer, Christian, Pampaloni, Francesco, Stelzer, Ernst H. K.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334646/
https://ncbi.nlm.nih.gov/pubmed/28255161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43693
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