Cholesterol impairment contributes to neuroserpin aggregation

Intraneural accumulation of misfolded proteins is a common feature of several neurodegenerative pathologies including Alzheimer’s and Parkinson’s diseases, and Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB). FENIB is a rare disease due to a point mutation in neuroserpin which acce...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Giampietro, Costanza, Lionetti, Maria Chiara, Costantini, Giulio, Mutti, Federico, Zapperi, Stefano, La Porta, Caterina A. M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334643/
https://ncbi.nlm.nih.gov/pubmed/28255164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43669
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