Increased PLEKHO1 within osteoblasts suppresses Smad‐dependent BMP signaling to inhibit bone formation during aging

Emerging evidence indicates that the dysregulation of protein ubiquitination plays a crucial role in aging‐associated diseases. Smad‐dependent canonical BMP signaling pathway is indispensable for osteoblastic bone formation, which could be disrupted by the ubiquitination and subsequent proteasomal d...

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Veröffentlicht in:Aging Cell
Hauptverfasser: Liu, Jin, Liang, Chao, Guo, Baosheng, Wu, Xiaohao, Li, Defang, Zhang, Zongkang, Zheng, Kang, Dang, Lei, He, Xiaojuan, Lu, Changwei, Peng, Songlin, Pan, Xiaohua, Zhang, Bao‐Ting, Lu, Aiping, Zhang, Ge
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334543/
https://ncbi.nlm.nih.gov/pubmed/28083909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12566
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