Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis

The underlying mechanism of the reduced bone formation during the development of glucocorticoid-induced osteoporosis (GIO) remains unclear. Here, we found that the highly expressed CKIP-1 together with lowly expressed total and phosphorylated Smad1/5 in bone samples was accompanied by either the red...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Liu, Jin, Lu, Changwei, Wu, Xiaohao, Zhang, Zongkang, Li, Jie, Guo, Baosheng, Li, Defang, Liang, Chao, Dang, Lei, Pan, Xiaohua, Peng, Songlin, Lu, Aiping, Zhang, Baoting, Zhang, Ge
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269586/
https://ncbi.nlm.nih.gov/pubmed/28128304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41295
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