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Effects of Aging and Oxidative Stress on Spermatozoa of Superoxide-Dismutase 1- and Catalase-Null Mice

Advanced paternal age is linked to complications in pregnancy and genetic diseases in offspring. Aging results in excess reactive oxygen species (ROS) and DNA damage in spermatozoa; this damage can be transmitted to progeny with detrimental consequences. Although there is a loss of antioxidants with...

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Publicado en:Biol Reprod
Autores principales: Selvaratnam, Johanna S., Robaire, Bernard
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for the Study of Reproduction, Inc. 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333935/
https://ncbi.nlm.nih.gov/pubmed/27465136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.116.141671
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