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In silico designing of a new cysteine analogue of hirudin variant 3 for site specific PEGylation

Hirudin is an anticoagulant agent of the salivary glands of the medicinal leech. Recombinant hirudin (r-Hir) displays certain drawbacks including bleeding and immunogenicity. To solve these problems, cysteine-specific PEGylation has been proposed as a successful technique. However, proper selection...

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Detalhes bibliográficos
Publicado no:Res Pharm Sci
Main Authors: Sajjadi, Seyed Mehdi, Rahimi, Hamzeh, Mohammadi, Saeed, Faranoush, Mohammad, Mirzahoseini, Hasan, Toogeh, Gholamreza
Formato: Artigo
Idioma:Inglês
Publicado em: Medknow Publications & Media Pvt Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333481/
https://ncbi.nlm.nih.gov/pubmed/28255315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1735-5362.199048
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