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In silico designing of a new cysteine analogue of hirudin variant 3 for site specific PEGylation
Hirudin is an anticoagulant agent of the salivary glands of the medicinal leech. Recombinant hirudin (r-Hir) displays certain drawbacks including bleeding and immunogenicity. To solve these problems, cysteine-specific PEGylation has been proposed as a successful technique. However, proper selection...
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Publicado no: | Res Pharm Sci |
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Main Authors: | , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Medknow Publications & Media Pvt Ltd
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5333481/ https://ncbi.nlm.nih.gov/pubmed/28255315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1735-5362.199048 |
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