A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis

BACKGROUND: Dysregulated WNT signaling dominates adrenocortical malignancies. This study investigates whether silencing of the WNT negative regulator DKK3 (Dickkopf-related protein 3), an implicated adrenocortical differentiation marker and an established tumor suppressor in multiple cancers, allows...

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Dades bibliogràfiques
Publicat a:BMC Cancer
Autors principals: Cheng, Joyce Y., Brown, Taylor C., Murtha, Timothy D., Stenman, Adam, Juhlin, C. Christofer, Larsson, Catharina, Healy, James M., Prasad, Manju L., Knoefel, Wolfram T., Krieg, Andreas, Scholl, Ute I., Korah, Reju, Carling, Tobias
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333434/
https://ncbi.nlm.nih.gov/pubmed/28249601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3152-5
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