A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis

BACKGROUND: Dysregulated WNT signaling dominates adrenocortical malignancies. This study investigates whether silencing of the WNT negative regulator DKK3 (Dickkopf-related protein 3), an implicated adrenocortical differentiation marker and an established tumor suppressor in multiple cancers, allows...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Cheng, Joyce Y., Brown, Taylor C., Murtha, Timothy D., Stenman, Adam, Juhlin, C. Christofer, Larsson, Catharina, Healy, James M., Prasad, Manju L., Knoefel, Wolfram T., Krieg, Andreas, Scholl, Ute I., Korah, Reju, Carling, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333434/
https://ncbi.nlm.nih.gov/pubmed/28249601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3152-5
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