A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis

BACKGROUND: Dysregulated WNT signaling dominates adrenocortical malignancies. This study investigates whether silencing of the WNT negative regulator DKK3 (Dickkopf-related protein 3), an implicated adrenocortical differentiation marker and an established tumor suppressor in multiple cancers, allows...

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Vydáno v:BMC Cancer
Hlavní autoři: Cheng, Joyce Y., Brown, Taylor C., Murtha, Timothy D., Stenman, Adam, Juhlin, C. Christofer, Larsson, Catharina, Healy, James M., Prasad, Manju L., Knoefel, Wolfram T., Krieg, Andreas, Scholl, Ute I., Korah, Reju, Carling, Tobias
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333434/
https://ncbi.nlm.nih.gov/pubmed/28249601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3152-5
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