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Transcriptional Signature of an Altered Purine Metabolism in the Skeletal Muscle of a Huntington's Disease Mouse Model

Huntington's disease (HD) is a fatal neurodegenerative disorder, caused by a polyglutamine expansion in the huntingtin protein (HTT). HD has a peripheral component to its pathology: skeletal muscles are severely affected, leading to atrophy, and malfunction in both pre-clinical and clinical set...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Mielcarek, Michal, Smolenski, Ryszard T., Isalan, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332388/
https://ncbi.nlm.nih.gov/pubmed/28303108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00127
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