Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis

Non-Alcoholic Fatty Liver Disease (NAFLD) is a major form of chronic liver disease in the general population in relation to its high prevalence among overweight/obese individuals and patients with diabetes type II or metabolic syndrome. NAFLD can progress to steatohepatitis (NASH), fibrosis and cirr...

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Udgivet i:PLoS One
Main Authors: Cannito, Stefania, Morello, Elisabetta, Bocca, Claudia, Foglia, Beatrice, Benetti, Elisa, Novo, Erica, Chiazza, Fausto, Rogazzo, Mara, Fantozzi, Roberto, Povero, Davide, Sutti, Salvatore, Bugianesi, Elisabetta, Feldstein, Ariel E., Albano, Emanuele, Collino, Massimo, Parola, Maurizio
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331985/
https://ncbi.nlm.nih.gov/pubmed/28249038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172575
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