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Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC

Lung cancer is the leading cause of cancer death in the US with ∼124,000 new cases annually, and a 5 y survival rate of ∼16%. Mutant KRAS-driven lung adenocarcinoma (KRAS LADC) is a particularly prevalent and deadly form of lung cancer. Protein kinase Cι (PKCι) is an oncogenic effector of KRAS that...

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Bibliografski detalji
Izdano u:Small GTPases
Glavni autori: Fields, Alan P., Ali, Syed A., Justilien, Verline, Murray, Nicole R.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331898/
https://ncbi.nlm.nih.gov/pubmed/27245608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2016.1194953
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