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KRas, ROS and the initiation of pancreatic cancer
Oncogenic mutations of KRAS are the most frequent driver mutations in pancreatic cancer. Expression of an oncogenic allele of KRAS leads to metabolic changes and altered cellular signaling that both can increase the production of intracellular reactive oxygen species (ROS). Increases in ROS have bee...
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| Publicado no: | Small GTPases |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5331894/ https://ncbi.nlm.nih.gov/pubmed/27215184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2016.1192714 |
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