Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1–AKT–mTOR Axis in Mice

BACKGROUND & AIMS: Hepatic cholesterol accumulation and autophagy defects contribute to hepatocyte injury in fatty liver disease. Bile acid synthesis is a major pathway for cholesterol catabolism in the liver. This study aims to understand the molecular link between cholesterol and bile acid met...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Wang, Yifeng, Ding, Yifeng, Li, Jibiao, Chavan, Hemantkumar, Matye, David, Ni, Hong-Min, Chiang, John Y.L., Krishnamurthy, Partha, Ding, Wen-Xing, Li, Tiangang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331786/
https://ncbi.nlm.nih.gov/pubmed/28275691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2016.10.002
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