A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages

An unresolved question is how HIV‐1 achieves efficient replication in terminally differentiated macrophages despite the restriction factor SAMHD1. We reveal inducible changes in expression of cell cycle‐associated proteins including MCM2 and cyclins A, E, D1/D3 in macrophages, without evidence for D...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Mlcochova, Petra, Sutherland, Katherine A, Watters, Sarah A, Bertoli, Cosetta, de Bruin, Rob AM, Rehwinkel, Jan, Neil, Stuart J, Lenzi, Gina M, Kim, Baek, Khwaja, Asim, Gage, Matthew C, Georgiou, Christiana, Chittka, Alexandra, Yona, Simon, Noursadeghi, Mahdad, Towers, Greg J, Gupta, Ravindra K
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331754/
https://ncbi.nlm.nih.gov/pubmed/28122869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201696025
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