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Vpx complementation of ‘non-macrophage tropic’ R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages

BACKGROUND: It is now known that clinically derived viruses are most commonly R5 tropic with very low infectivity in macrophages. As these viruses utilize CD4 inefficiently, defective entry has been assumed to be the dominant restriction. The implication is that macrophages are not an important rese...

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Detalhes bibliográficos
Main Authors: Mlcochova, Petra, Watters, Sarah A, Towers, Greg J, Noursadeghi, Mahdad, Gupta, Ravindra K
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997928/
https://ncbi.nlm.nih.gov/pubmed/24656066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-11-25
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