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Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation
The human RIF1 protein controls DNA replication, but the molecular mechanism is largely unknown. Here, we demonstrate that human RIF1 negatively regulates DNA replication by forming a complex with protein phosphatase 1 (PP1) that limits phosphorylation‐mediated activation of the MCM replicative heli...
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| Publicado no: | EMBO Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5331243/ https://ncbi.nlm.nih.gov/pubmed/28077461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201641983 |
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