Cabozantinib: an Active Novel Multikinase Inhibitor in Renal Cell Carcinoma

Clear cell renal cell carcinoma (RCC) is characterized by inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene. VHL loss drives tumor angiogenesis and accounts for the clinical activity of VEGF receptor (VEGFR) tyrosine kinase inhibitors (TKIs), the first-line standard of care for advan...

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Bibliographic Details
Published in:Curr Oncol Rep
Main Authors: Tannir, Nizar M., Schwab, Gisela, Grünwald, Viktor
Format: Artigo
Language:Inglês
Published: Springer US 2017
Subjects:
Evolving Therapies (R Bukowski, Section Editor)
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331092/
https://ncbi.nlm.nih.gov/pubmed/28247252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11912-017-0566-9
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