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Human motoneurone excitability is depressed by activation of serotonin 1A receptors with buspirone

KEY POINTS: In the adult turtle spinal cord, action potential generation in motoneurones is inhibited by spillover of serotonin to extrasynaptic serotonin 1A (5‐HT(1A)) receptors at the axon initial segment. We explored whether ingestion of the 5‐HT(1A) receptor partial agonist, buspirone, decreases...

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Pubblicato in:J Physiol
Autori principali: D'Amico, Jessica M., Butler, Annie A., Héroux, Martin E., Cotel, Florence, Perrier, Jean‐François M., Butler, Jane E., Gandevia, Simon C., Taylor, Janet L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330870/
https://ncbi.nlm.nih.gov/pubmed/27859267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273200
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