Human motoneurone excitability is depressed by activation of serotonin 1A receptors with buspirone

KEY POINTS: In the adult turtle spinal cord, action potential generation in motoneurones is inhibited by spillover of serotonin to extrasynaptic serotonin 1A (5‐HT(1A)) receptors at the axon initial segment. We explored whether ingestion of the 5‐HT(1A) receptor partial agonist, buspirone, decreases...

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Publicat a:J Physiol
Autors principals: D'Amico, Jessica M., Butler, Annie A., Héroux, Martin E., Cotel, Florence, Perrier, Jean‐François M., Butler, Jane E., Gandevia, Simon C., Taylor, Janet L.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Neuroscience ‐ Behavioural/Systems/Cognitive
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330870/
https://ncbi.nlm.nih.gov/pubmed/27859267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273200
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