A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

Elevated expression of the chemokine receptor CCR4 in tumors is associated with poor prognosis in several cancers. Here, we have determined that CCR4 was highly expressed in human renal cell carcinoma (RCC) biopsies and observed abnormal levels of CCR4 ligands in RCC patient plasma. An antagonistic...

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Publicado en:J Clin Invest
Autores principales: Berlato, Chiara, Khan, Moddasar N., Schioppa, Tiziana, Thompson, Richard, Maniati, Eleni, Montfort, Anne, Jangani, Maryam, Canosa, Monica, Kulbe, Hagen, Hagemann, Urs B., Duncan, Alexander R., Fletcher, Laura, Wilkinson, Robert W., Powles, Thomas, Quezada, Sergio A., Balkwill, Frances R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330727/
https://ncbi.nlm.nih.gov/pubmed/28134623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82976
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