A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

Elevated expression of the chemokine receptor CCR4 in tumors is associated with poor prognosis in several cancers. Here, we have determined that CCR4 was highly expressed in human renal cell carcinoma (RCC) biopsies and observed abnormal levels of CCR4 ligands in RCC patient plasma. An antagonistic...

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Publicat a:J Clin Invest
Autors principals: Berlato, Chiara, Khan, Moddasar N., Schioppa, Tiziana, Thompson, Richard, Maniati, Eleni, Montfort, Anne, Jangani, Maryam, Canosa, Monica, Kulbe, Hagen, Hagemann, Urs B., Duncan, Alexander R., Fletcher, Laura, Wilkinson, Robert W., Powles, Thomas, Quezada, Sergio A., Balkwill, Frances R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330727/
https://ncbi.nlm.nih.gov/pubmed/28134623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82976
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