Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

Chimeric antigen receptor (CAR) T cells have been highly successful in treating hematological malignancies, including acute and chronic lymphoblastic leukemia. However, treatment of solid tumors using CAR T cells has been largely unsuccessful to date, partly because of tumor-induced immunosuppressiv...

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Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: Beavis, Paul A., Henderson, Melissa A., Giuffrida, Lauren, Mills, Jane K., Sek, Kevin, Cross, Ryan S., Davenport, Alexander J., John, Liza B., Mardiana, Sherly, Slaney, Clare Y., Johnstone, Ricky W., Trapani, Joseph A., Stagg, John, Loi, Sherene, Kats, Lev, Gyorki, David, Kershaw, Michael H., Darcy, Phillip K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2017
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330718/
https://ncbi.nlm.nih.gov/pubmed/28165340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89455
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