Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunological and Clinical Outcomes

PURPOSE: We have clinically evaluated a DNA fusion vaccine to target the HLA-A*0201 binding peptide CAP-1 from carcinoembryonic antigen (CEA(605–613)) linked to an immunostimulatory domain (DOM) from fragment C of tetanus toxin. EXPERIMENTAL DESIGN: Twenty-seven patients with CEA-expressing carcinom...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: McCann, Katy J., Mander, Ann, Cazaly, Angelica, Chudley, Lindsey, Stasakova, Jana, Thirdborough, Stephen, King, Andrew, Lloyd-Evans, Paul, Buxton, Emily, Edwards, Ceri, Halford, Sarah, Bateman, Andrew, O’Callaghan, Ann, Clive, Sally, Anthoney, Alan, Jodrell, Duncan I., Weinschenk, Toni, Simon, Petra, Sahin, Ugur, Thomas, Gareth J., Stevenson, Freda K., Ottensmeier, Christian H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330406/
https://ncbi.nlm.nih.gov/pubmed/27091407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2507
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