Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation.

Incubation of intact rat fat cells with maximally effective concentrations of insulin (1 nM, 12 min) or isoprenaline (300 nM, 3 min) increased particulate cGMP- and cilostamide-inhibited, low-Km cAMP phosphodiesterase (cAMP-PDE) activity by about 50% and 100%, respectively. In 32P-labeled cells, the...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Degerman, E, Smith, C J, Tornqvist, H, Vasta, V, Belfrage, P, Manganiello, V C
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1990
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53299/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2153956/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.2.533
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