E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia

Friedreich ataxia (FRDA) is a severe genetic neurodegenerative disease caused by reduced expression of the mitochondrial protein frataxin. To date, there is no therapy to treat this condition. The amount of residual frataxin critically affects the severity of the disease; thus, attempts to restore p...

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Vydáno v:Cell Rep
Hlavní autoři: Benini, Monica, Fortuni, Silvia, Condò, Ivano, Alfedi, Giulia, Malisan, Florence, Toschi, Nicola, Serio, Dario, Massaro, Damiano Sergio, Arcuri, Gaetano, Testi, Roberto, Rufini, Alessandra
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5329121/
https://ncbi.nlm.nih.gov/pubmed/28228265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.01.079
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