[Pyr(1)]Apelin-13((1–12)) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr(1)]Apelin-13

Aims: Apelin is a predicted substrate for ACE2, a novel therapeutic target. Our aim was to demonstrate the endogenous presence of the putative ACE2 product [Pyr(1)]apelin-13((1–12)) in human cardiovascular tissues and to confirm it retains significant biological activity for the apelin receptor in v...

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Bibliographic Details
Published in:Front Neurosci
Main Authors: Yang, Peiran, Kuc, Rhoda E., Brame, Aimée L., Dyson, Alex, Singer, Mervyn, Glen, Robert C., Cheriyan, Joseph, Wilkinson, Ian B., Davenport, Anthony P., Maguire, Janet J.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5329011/
https://ncbi.nlm.nih.gov/pubmed/28293165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2017.00092
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