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Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension

CONTEXT: Hypotension is one of the dose limiting side effects of benzodiazepines (BZDs), in particular of diazepam (DZP) which is still widely used in the clinic. Currently, only one FDA approved antidote exists for BZD overdose and novel approaches are needed to improve management of DZP overdose,...

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Détails bibliographiques
Publié dans:J Clin Toxicol
Auteurs principaux: Ulu, Arzu, Inceoglu, Bora, Yang, Jun, Singh, Vikrant, Vito, Stephen, Wulff, Heike, Hammock, Bruce D
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328659/
https://ncbi.nlm.nih.gov/pubmed/28255523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/2161-0495.1000300
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