Reduced Chance of Hearing Loss Associated with Therapeutic Drug Monitoring of Aminoglycosides in the Treatment of Multidrug-Resistant Tuberculosis

Hearing loss and nephrotoxicity are associated with prolonged treatment duration and higher dosage of amikacin and kanamycin. In our tuberculosis center, we used therapeutic drug monitoring (TDM) targeting preset pharmacokinetic/pharmacodynamic (PK/PD) surrogate endpoints in an attempt to maintain e...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: van Altena, R., Dijkstra, J. A., van der Meer, M. E., Borjas Howard, J. F., Kosterink, J. G. W., van Soolingen, D., van der Werf, T. S., Alffenaar, J. W. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328543/
https://ncbi.nlm.nih.gov/pubmed/28069654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01400-16
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