Pseudomonas aeruginosa Oligoribonuclease Contributes to Tolerance to Ciprofloxacin by Regulating Pyocin Biosynthesis

Bacterial oligoribonuclease (Orn) is a conserved 3′-to-5′ exonuclease. In Pseudomonas aeruginosa, it has been demonstrated that Orn plays a major role in the hydrolysis of pGpG, which is required for cyclic-di-GMP homeostasis. Meanwhile, Orn is involved in the degradation of nanoRNAs, which can alte...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Chen, Fei, Chen, Gukui, Liu, Yiwei, Jin, Yongxin, Cheng, Zhihui, Liu, Yang, Yang, Liang, Jin, Shouguang, Wu, Weihui
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328516/
https://ncbi.nlm.nih.gov/pubmed/28052848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02256-16
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