Dapagliflozin Binds Specifically to Sodium-Glucose Cotransporter 2 in the Proximal Renal Tubule

Kidneys contribute to glucose homeostasis by reabsorbing filtered glucose in the proximal tubules via sodium-glucose cotransporters (SGLTs). Reabsorption is primarily handled by SGLT2, and SGLT2-specific inhibitors, including dapagliflozin, canagliflozin, and empagliflozin, increase glucose excretio...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Am Soc Nephrol
Auteurs principaux: Ghezzi, Chiara, Yu, Amy S., Hirayama, Bruce A., Kepe, Vladimir, Liu, Jie, Scafoglio, Claudio, Powell, David R., Huang, Sung-Cheng, Satyamurthy, Nagichettiar, Barrio, Jorge R., Wright, Ernest M.
Format: Artigo
Langue:Inglês
Publié: American Society of Nephrology 2017
Sujets:
Basic Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328165/
https://ncbi.nlm.nih.gov/pubmed/27620988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016050510
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