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Dynamic conformational changes in the rhesus TRIM5α dimer dictate the potency of HIV-1 restriction
The TRIM5α protein from rhesus macaques (rhTRIM5α) mediates a potent inhibition of HIV-1 infection via a mechanism that involves the abortive disassembly of the viral core. We have demonstrated that alpha-helical elements within the Linker 2 (L2) region, which lies between the SPRY domain and the Co...
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| Pubblicato in: | Virology |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5327651/ https://ncbi.nlm.nih.gov/pubmed/27821283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.10.003 |
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