Dynamic conformational changes in the rhesus TRIM5α dimer dictate the potency of HIV-1 restriction

The TRIM5α protein from rhesus macaques (rhTRIM5α) mediates a potent inhibition of HIV-1 infection via a mechanism that involves the abortive disassembly of the viral core. We have demonstrated that alpha-helical elements within the Linker 2 (L2) region, which lies between the SPRY domain and the Co...

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Bibliografiska uppgifter
I publikationen:Virology
Huvudupphovsmän: Lamichhane, Rajan, Mukherjee, Santanu, Smolin, Nikolai, Pauszek, Raymond F, Bradley, Margret, Sastri, Jaya, Robia, Seth L., Millar, David, Campbell, Edward M
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5327651/
https://ncbi.nlm.nih.gov/pubmed/27821283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.10.003
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