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D-cycloserine in Schizophrenia: New Strategies for Improving Clinical Outcomes by Enhancing Plasticity

BACKGROUND: Dysregulation of N-methyl D-aspartate (NMDA) receptor signaling is strongly implicated in schizophrenia. Based on the ketamine model of NMDA receptor hypoactivity, therapeutic approaches designed to maintain a sustained increase in agonist activity at the glycine site of the NMDA recepto...

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Detalhes bibliográficos
Publicado no:Curr Neuropharmacol
Autor principal: Goff, Donald C.
Formato: Artigo
Idioma:Inglês
Publicado em: Bentham Science Publishers 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5327448/
https://ncbi.nlm.nih.gov/pubmed/26915421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1570159X14666160225154812
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