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Nrf2-dependent induction of innate host defense via heme oxygenase-1 inhibits Zika virus replication
We identified primary human monocyte-derived macrophages (MDM) as vulnerable target cells for Zika virus (ZIKV) infection. We demonstrate dramatic effects of hemin, the natural inducer of the heme catabolic enzyme heme oxygenase-1 (HO-1), in the reduction of ZIKV replication in vitro. Both LLC-MK2 m...
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| Vydáno v: | Virology |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5325777/ https://ncbi.nlm.nih.gov/pubmed/28068513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.12.019 |
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