Phosphorylation of β-arrestin2 at Thr(383) by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs

In addition to their role in desensitization and internalization of G protein-coupled receptors (GPCRs), β-arrestins are essential scaffolds linking GPCRs to Erk1/2 signaling. However, their role in GPCR-operated Erk1/2 activation differs between GPCRs and the underlying mechanism remains poorly cha...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Cassier, Elisabeth, Gallay, Nathalie, Bourquard, Thomas, Claeysen, Sylvie, Bockaert, Joël, Crépieux, Pascale, Poupon, Anne, Reiter, Eric, Marin, Philippe, Vandermoere, Franck
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2017
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325621/
https://ncbi.nlm.nih.gov/pubmed/28169830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23777
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