تحميل...

Rational design of DKK3 structure-based small peptides as antagonists of Wnt signaling pathway and in silico evaluation of their efficiency

Dysregulated Wnt signaling pathway is highly associated with the pathogenesis of several human cancers. Dickkopf proteins (DKKs) are thought to inhibit Wnt signaling pathway through binding to lipoprotein receptor-related protein (LRP) 5/6. In this study, based on the 3-dimensional (3D) structure of...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:PLoS One
المؤلفون الرئيسيون: Poorebrahim, Mansour, Sadeghi, Solmaz, Rahimi, Hamzeh, Karimipoor, Morteza, Azadmanesh, Kayhan, Mazlomi, Mohammad Ali, Teimoori-Toolabi, Ladan
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2017
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325476/
https://ncbi.nlm.nih.gov/pubmed/28234935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172217
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