Rational design of DKK3 structure-based small peptides as antagonists of Wnt signaling pathway and in silico evaluation of their efficiency

Dysregulated Wnt signaling pathway is highly associated with the pathogenesis of several human cancers. Dickkopf proteins (DKKs) are thought to inhibit Wnt signaling pathway through binding to lipoprotein receptor-related protein (LRP) 5/6. In this study, based on the 3-dimensional (3D) structure of...

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Foilsithe in:PLoS One
Main Authors: Poorebrahim, Mansour, Sadeghi, Solmaz, Rahimi, Hamzeh, Karimipoor, Morteza, Azadmanesh, Kayhan, Mazlomi, Mohammad Ali, Teimoori-Toolabi, Ladan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2017
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325476/
https://ncbi.nlm.nih.gov/pubmed/28234935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172217
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