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Rational design of DKK3 structure-based small peptides as antagonists of Wnt signaling pathway and in silico evaluation of their efficiency

Dysregulated Wnt signaling pathway is highly associated with the pathogenesis of several human cancers. Dickkopf proteins (DKKs) are thought to inhibit Wnt signaling pathway through binding to lipoprotein receptor-related protein (LRP) 5/6. In this study, based on the 3-dimensional (3D) structure of...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Poorebrahim, Mansour, Sadeghi, Solmaz, Rahimi, Hamzeh, Karimipoor, Morteza, Azadmanesh, Kayhan, Mazlomi, Mohammad Ali, Teimoori-Toolabi, Ladan
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325476/
https://ncbi.nlm.nih.gov/pubmed/28234935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172217
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