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Modeling of signaling crosstalk-mediated drug resistance and its implications on drug combination

The efficacy of pharmacological perturbation to the signaling transduction network depends on the network topology. However, whether and how signaling dynamics mediated by crosstalk contributes to the drug resistance are not fully understood and remain to be systematically explored. In this study, m...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Sun, Xiaoqiang, Bao, Jiguang, You, Zhuhong, Chen, Xing, Cui, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325420/
https://ncbi.nlm.nih.gov/pubmed/27590512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11745
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