Adrenomedullin blockade suppresses sunitinib-resistant renal cell carcinoma growth by targeting the ERK/MAPK pathway

PURPOSE: To evaluate the mechanisms underlying sunitinib resistance in RCC and to identify targets that may be used to overcome this resistance. RESULTS: Reanalysis of transcriptome microarray datasets (GSE64052 and GSE76068) showed that adrenomedullin expression was increased in sunitinib-resistant...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Gao, Yongqian, Li, Jinyi, Qiao, Na, Meng, Qingsong, Zhang, Ming, Wang, Xin, Jia, Jianghua, Yang, Shuwen, Qu, Changbao, Li, Wei, Wang, Dongbin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325371/
https://ncbi.nlm.nih.gov/pubmed/27556517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11463
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