Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer

UTX is a histone demethylase gene located on the X chromosome and is a frequently mutated gene in urothelial bladder cancer (UBC). UTY is a paralog of UTX located on the Y chromosome. We performed target capture sequencing on 128 genes in 40 non-metastatic UBC patients. UTX was the most frequently m...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ahn, Jinwoo, Kim, Kwang Hyun, Park, Sanghui, Ahn, Young-Ho, Kim, Ha Young, Yoon, Hana, Lee, Ji Hyun, Bang, Duhee, Lee, Dong Hyeon
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325361/
https://ncbi.nlm.nih.gov/pubmed/27533081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11207
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